Mutant Boxing League VR was developed and published by Filmic Studios, conceived by creative director Marcus who wanted a more dynamic alternative to traditional gym workouts. Unlike Thrill of the Fight 2 and True Boxing VR, both of which aim for technical boxing authenticity, Mutant Boxing League leans into stylised arcade energy — mutant opponents, special equipment, and a structure that one SideQuest reviewer summarised perfectly: "Reminds me of Super Punch Out but in VR!"

The game was developed with input from professional boxers to ensure the training remains both enjoyable and physically effective despite its arcade presentation. Players progress through matches against opponents with distinct styles and tricks, unlocking new environments and glove skins along the way. Special equipment — the Power Glove and Speed Glove — introduces tactical variety beyond simple punch-and-block mechanics, each requiring its own technique to use effectively, taught through in-game tutorials.